3UDD

Tankyrase-1 in complex with small molecule inhibitor

3UDD の概要

• エントリーDOI: 10.2210/pdb3udd/pdb
• 分子名称: Tankyrase-1, ZINC ION, 3-(4-methoxyphenyl)-5-({[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)-1,2,4-oxadiazole, ... (6 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: O95271
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52713.92

構造登録者

Kirby, C.A.,Stams, T. (登録日: 2011-10-28, 公開日: 2012-02-01, 最終更新日: 2024-02-28)

• 主引用文献: Shultz, M.D.,Kirby, C.A.,Stams, T.,Chin, D.N.,Blank, J.,Charlat, O.,Cheng, H.,Cheung, A.,Cong, F.,Feng, Y.,Fortin, P.D.,Hood, T.,Tyagi, V.,Xu, M.,Zhang, B.,Shao, W.; [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.; J.Med.Chem., 55:1127-1136, 2012; PubMed: 22260203; DOI: 10.1021/jm2011222

実験手法

X-RAY DIFFRACTION (1.95 Å)