3UCB

Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir

3UCB の概要

• エントリーDOI: 10.2210/pdb3ucb/pdb
• 関連するPDBエントリー: 3UF3 3UFN 3UHL
• 分子名称: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22628.41

構造登録者

Agniswamy, J.,Chen-Hsiang, S.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T. (登録日: 2011-10-26, 公開日: 2012-03-28, 最終更新日: 2023-09-13)

• 主引用文献: Agniswamy, J.,Shen, C.H.,Aniana, A.,Sayer, J.M.,Louis, J.M.,Weber, I.T.; HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.; Biochemistry, 51:2819-2828, 2012; PubMed: 22404139; DOI: 10.1021/bi2018317

実験手法

X-RAY DIFFRACTION (1.38 Å)