3UBU

Crystal structure of agkisacucetin, a GpIb-binding snaclec (snake C-type lectin) that inhibits platelet

3UBU の概要

• エントリーDOI: 10.2210/pdb3ubu/pdb
• 分子名称: Agglucetin subunit alpha-1, Agglucetin subunit beta-2, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: platelet inhibiting, agkisacucetin, dimer, toxin, c-type lectin-like, gpib inhibitor, gpib binding
• 由来する生物種: Deinagkistrodon acutus (Hundred-pace snake); 詳細
• 細胞内の位置: Secreted (By similarity): Q8JIV9 Q8AYA3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30155.93

構造登録者

Gao, Y.,Ge, H.,Chen, H.,Li, H.,Liu, Y.,Niu, L.,Teng, M. (登録日: 2011-10-25, 公開日: 2012-04-11, 最終更新日: 2025-03-26)

主引用文献

Gao, Y.,Ge, H.,Chen, H.,Li, H.,Liu, Y.,Chen, L.,Li, X.,Liu, J.,Niu, L.,Teng, M.
Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation.
Proteins, 2012

PubMed Abstract: Agkisacucetin is a snake C-type lectin isolated from the venom of Agkistrodon acutus (A. acutus). It binds specifically to the platelet glycoprotein (GP) Ib and prevents the von Willebrand factor (VWF) accessing it. We determined the crystal structure of agkisacucetin to 1.9Å resolution. The structure of agkisacucetin has an (αβ) fold similar to another GPIb-binding protein, flavocetin-A, but lacks the C-terminal cysteine in the β-subunit, does not form (βα)(4) tetramers, and does not cluster GPIbs, like flavocetin-A.

PubMed: 22447656
DOI: 10.1002/prot.24060

実験手法

X-RAY DIFFRACTION (1.91 Å)