3UAS

Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene

3UAS の概要

• エントリーDOI: 10.2210/pdb3uas/pdb
• 分子名称: Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, phenanthren-9-ylacetaldehyde, ... (6 entities in total)
• 機能のキーワード: p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55826.84

構造登録者

Gay, S.C.,Zhang, H.,Shah, M.B.,Stout, C.D.,Halpert, J.R.,Hollenberg, P.F. (登録日: 2011-10-21, 公開日: 2013-01-09, 最終更新日: 2023-09-13)

• 主引用文献: Zhang, H.,Gay, S.C.,Shah, M.,Foroozesh, M.,Liu, J.,Osawa, Y.,Zhang, Q.,Stout, C.D.,Halpert, J.R.,Hollenberg, P.F.; Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis.; Biochemistry, 52:355-364, 2013; PubMed: 23276288; DOI: 10.1021/bi301567z

実験手法

X-RAY DIFFRACTION (2.939 Å)