3UA1
Crystal structure of the cytochrome P4503A4-bromoergocryptine complex
Summary for 3UA1
Entry DOI | 10.2210/pdb3ua1/pdb |
Related | 1TQN 2JOD 2VOM 3NXU |
Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, bromoergocryptine, ... (4 entities in total) |
Functional Keywords | protein-substrate complex, monooxygenase, cytochrome p450 reductase, cytochrome b5, membrane, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P08684 |
Total number of polymer chains | 1 |
Total formula weight | 57028.89 |
Authors | Sevrioukova, I.F.,Poulos, T.L. (deposition date: 2011-10-20, release date: 2011-12-14, Last modification date: 2023-09-13) |
Primary citation | Sevrioukova, I.F.,Poulos, T.L. Structural and Mechanistic Insights into the Interaction of Cytochrome P4503A4 with Bromoergocryptine, a Type I Ligand. J.Biol.Chem., 287:3510-3517, 2012 Cited by PubMed: 22157006DOI: 10.1074/jbc.M111.317081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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