3U9U

Crystal Structure of Extracellular Domain of Human ErbB4/Her4 in complex with the Fab fragment of mAb1479

Summary for 3U9U

Entry DOI	10.2210/pdb3u9u/pdb
Descriptor	Fab Heavy Chain, Fab Light Chain, Receptor tyrosine-protein kinase erbB-4 (3 entities in total)
Functional Keywords	cell surface receptor, transferase, tyrosine kinase receptor
Biological source	Mus musculus (mouse) More
Cellular location	Cell membrane ; Single-pass type I membrane protein . ERBB4 intracellular domain: Nucleus : Q15303
Total number of polymer chains	6
Total formula weight	236537.40
Authors	Hollmen, M.,Liu, P.,Wildiers, H.,Reinvall, I.,Vandorpe, T.,Smeets, A.,Deraedt, K.,Vahlberg, T.,Joensuu, H.,Leahy, D.J.,Schoffski, P.,Elenius, K. (deposition date: 2011-10-19, release date: 2012-10-31, Last modification date: 2023-09-13)
Primary citation	Hollmen, M.,Liu, P.,Kurppa, K.,Wildiers, H.,Reinvall, I.,Vandorpe, T.,Smeets, A.,Deraedt, K.,Vahlberg, T.,Joensuu, H.,Leahy, D.J.,Schoffski, P.,Elenius, K. Proteolytic processing of ErbB4 in breast cancer. Plos One, 7:e39413-e39413, 2012 Cited by PubMed: 22761786 DOI: 10.1371/journal.pone.0039413 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.42 Å)

Structure validation