3U9N
X-ray crystal structure of compound 1 bound to human CHK1 kinase domain
Summary for 3U9N
Entry DOI | 10.2210/pdb3u9n/pdb |
Related | 3PA3 3PA4 3PA5 |
Descriptor | Serine/threonine-protein kinase Chk1, 2-(2,3-dihydro-1-benzofuran-5-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide (3 entities in total) |
Functional Keywords | protein kinase domain, atpase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 31861.73 |
Authors | Fischmann, T.O. (deposition date: 2011-10-19, release date: 2012-01-25, Last modification date: 2024-02-28) |
Primary citation | Huang, X.,Cheng, C.C.,Fischmann, T.O.,Duca, J.S.,Yang, X.,Richards, M.,Shipps Jr., G.W. Discovery of a Novel Series of CHK1 Kinase Inhibitors with Distinctive Hinge Binding Mode ACS MED.CHEM.LETT., 2012 |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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