3U8Z

human merlin FERM domain

Summary for 3U8Z

• Entry DOI: 10.2210/pdb3u8z/pdb
• Descriptor: Merlin (2 entities in total)
• Functional Keywords: neurofibromatosis, tumor suppressor, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Cell projection, filopodium membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 7: Cytoplasm, perinuclear region. Isoform 9: Cytoplasm, perinuclear region. Isoform 10: Nucleus: P35240
• Total number of polymer chains: 4
• Total formula weight: 141775.83

Authors

Yogesha, S.D.,Sharff, A.J.,Giovannini, M.,Bricogne, G.,Izard, T. (deposition date: 2011-10-17, release date: 2011-11-02, Last modification date: 2023-09-13)

• Primary citation: Yogesha, S.D.,Sharff, A.J.,Giovannini, M.,Bricogne, G.,Izard, T.; Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.; Protein Sci., 20:2113-2120, 2011; PubMed: 22012890; DOI: 10.1002/pro.751

Experimental method

X-RAY DIFFRACTION (2.64 Å)