3U8J

Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3531 (1-(pyridin-3-yl)-1,4-diazepane)

Summary for 3U8J

• Entry DOI: 10.2210/pdb3u8j/pdb
• Related: 1UV6 1UW6 3U8K 3U8L 3U8M 3U8N
• Descriptor: Acetylcholine-binding protein, 1-(pyridin-3-yl)-1,4-diazepane, SULFATE ION, ... (5 entities in total)
• Functional Keywords: lymnaea stagnalis, agonist, ligand-bindig domain, acetylcholine, acetylcholine-binding protein, acetylcholine-binding protein-agonist complex, acetylcholine-binding protein/agonist
• Biological source: Lymnaea stagnalis (Great pond snail)
• Cellular location: Secreted: P58154
• Total number of polymer chains: 10
• Total formula weight: 241195.28

Authors

Rohde, L.A.H.,Ahring, P.K.,Jensen, M.L.,Nielsen, E.O.,Peters, D.,Helgstrand, C.,Krintel, C.,Harpsoe, K.,Gajhede, M.,Kastrup, J.S.,Balle, T. (deposition date: 2011-10-17, release date: 2011-12-14, Last modification date: 2023-09-13)

• Primary citation: Rohde, L.A.,Ahring, P.K.,Jensen, M.L.,Nielsen, E.,Peters, D.,Helgstrand, C.,Krintel, C.,Harpse, K.,Gajhede, M.,Kastrup, J.S.,Balle, T.; Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.; J.Biol.Chem., 287:4248-4259, 2012; PubMed: 22170047; DOI: 10.1074/jbc.M111.292243

Experimental method

X-RAY DIFFRACTION (2.35 Å)