3U8J

Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3531 (1-(pyridin-3-yl)-1,4-diazepane)

3U8J の概要

• エントリーDOI: 10.2210/pdb3u8j/pdb
• 関連するPDBエントリー: 1UV6 1UW6 3U8K 3U8L 3U8M 3U8N
• 分子名称: Acetylcholine-binding protein, 1-(pyridin-3-yl)-1,4-diazepane, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: lymnaea stagnalis, agonist, ligand-bindig domain, acetylcholine, acetylcholine-binding protein, acetylcholine-binding protein-agonist complex, acetylcholine-binding protein/agonist
• 由来する生物種: Lymnaea stagnalis (Great pond snail)
• 細胞内の位置: Secreted: P58154
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 241195.28

構造登録者

Rohde, L.A.H.,Ahring, P.K.,Jensen, M.L.,Nielsen, E.O.,Peters, D.,Helgstrand, C.,Krintel, C.,Harpsoe, K.,Gajhede, M.,Kastrup, J.S.,Balle, T. (登録日: 2011-10-17, 公開日: 2011-12-14, 最終更新日: 2023-09-13)

• 主引用文献: Rohde, L.A.,Ahring, P.K.,Jensen, M.L.,Nielsen, E.,Peters, D.,Helgstrand, C.,Krintel, C.,Harpse, K.,Gajhede, M.,Kastrup, J.S.,Balle, T.; Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha 4 beta 2 receptors: unique role of halogen bonding revealed.; J.Biol.Chem., 287:4248-4259, 2012; PubMed: 22170047; DOI: 10.1074/jbc.M111.292243

実験手法

X-RAY DIFFRACTION (2.35 Å)