3U7U

Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta

Summary for 3U7U

Entry DOI	10.2210/pdb3u7u/pdb
Descriptor	Receptor tyrosine-protein kinase erbB-4, Neuregulin 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	signaling protein, transferase-transferase regulator complex, glycosylation, transferase/transferase regulator
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	455341.19
Authors	Liu, P.,Cleveland IV, T.E.,Bouyain, S.,Longo, P.A.,Leahy, D.J. (deposition date: 2011-10-14, release date: 2012-08-29, Last modification date: 2023-09-13)
Primary citation	Liu, P.,Cleveland, T.E.,Bouyain, S.,Byrne, P.O.,Longo, P.A.,Leahy, D.J. A single ligand is sufficient to activate EGFR dimers. Proc.Natl.Acad.Sci.USA, 109:10861-10866, 2012 Cited by PubMed: 22699492 DOI: 10.1073/pnas.1201114109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.03 Å)

Structure validation