3U4U

Casein kinase 2 in complex with AZ-Inhibitor

3U4U の概要

• エントリーDOI: 10.2210/pdb3u4u/pdb
• 分子名称: Casein kinase II subunit alpha, 3-{5-(acetylamino)-3-[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]-1H-indol-1-yl}propanoic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: kinase, transferase, inhibitor binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40357.41

構造登録者

Larsen, N.A.,Dowling, J. (登録日: 2011-10-10, 公開日: 2012-08-22, 最終更新日: 2024-02-28)

• 主引用文献: Dowling, J.E.,Chuaqui, C.,Pontz, T.W.,Lyne, P.D.,Larsen, N.A.,Block, M.H.,Chen, H.,Su, N.,Wu, A.,Russell, D.,Pollard, H.,Lee, J.W.,Peng, B.,Thakur, K.,Ye, Q.,Zhang, T.,Brassil, P.,Racicot, V.,Bao, L.,Denz, C.R.,Cooke, E.; Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.; ACS Med Chem Lett, 3:278-283, 2012; PubMed: 24900464; DOI: 10.1021/ml200257n

実験手法

X-RAY DIFFRACTION (2.2 Å)