3U4S

Histone Lysine demethylase JMJD2A in complex with T11C peptide substrate crosslinked to N-oxalyl-D-cysteine

Summary for 3U4S

• Entry DOI: 10.2210/pdb3u4s/pdb
• Related: 2OQ6
• Descriptor: Lysine-specific demethylase 4A, HISTONE 3 TAIL ANALOG (T11C Peptide), NICKEL (II) ION, ... (6 entities in total)
• Functional Keywords: double-stranded beta-helix, demethylase, histone 3 tail, nucleus, oxidoreductase-oxidoreductase substrate complex, oxidoreductase/oxidoreductase substrate
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O75164 P68431
• Total number of polymer chains: 4
• Total formula weight: 90989.21

Authors

Ma, J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2011-10-10, release date: 2012-02-08, Last modification date: 2024-02-28)

• Primary citation: Woon, E.C.,Tumber, A.,Kawamura, A.,Hillringhaus, L.,Ge, W.,Rose, N.R.,Ma, J.H.,Chan, M.C.,Walport, L.J.,Che, K.H.,Ng, S.S.,Marsden, B.D.,Oppermann, U.,McDonough, M.A.,Schofield, C.J.; Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.; Angew.Chem.Int.Ed.Engl., 51:1631-1634, 2012; PubMed: 22241642; DOI: 10.1002/anie.201107833

Experimental method

X-RAY DIFFRACTION (2.15 Å)