3U4H

CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template

Summary for 3U4H

• Entry DOI: 10.2210/pdb3u4h/pdb
• Related: 3U4I
• Descriptor: ADP-ribosyl cyclase 1, 8-Amino-N1-Cyclic Inosine 5'-Diphosphoribose (3 entities in total)
• Functional Keywords: non-hydrolyzable inhibitor, two domains, cadpr cyclization, hydrolysis, 8-amino-n1-cidpr, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type II membrane protein: P28907
• Total number of polymer chains: 2
• Total formula weight: 61875.39

Authors

Liu, Q.,Hao, Q.,Lee, H.C.,Graeff, R. (deposition date: 2011-10-08, release date: 2012-10-10, Last modification date: 2023-11-01)

• Primary citation: Moreau, C.,Liu, Q.,Graeff, R.,Wagner, G.K.,Thomas, M.P.,Swarbrick, J.M.,Shuto, S.,Lee, H.C.,Hao, Q.,Potter, B.V.L.; CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template; Plos One, 8:e66247-e66247, 2013; PubMed: 23840430; DOI: 10.1371/journal.pone.0066247

Experimental method

X-RAY DIFFRACTION (1.878 Å)