3U3Z
Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142
Summary for 3U3Z
Entry DOI | 10.2210/pdb3u3z/pdb |
Descriptor | Microcephalin, Histone H2A.X peptide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | dna repair, cell cycle regulation, cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton, centrosome: Q8NEM0 |
Total number of polymer chains | 2 |
Total formula weight | 22819.21 |
Authors | Singh, N.,Thompson, J.R.,Heroux, A.,Mer, G. (deposition date: 2011-10-06, release date: 2012-07-25, Last modification date: 2023-12-06) |
Primary citation | Singh, N.,Basnet, H.,Wiltshire, T.D.,Mohammad, D.H.,Thompson, J.R.,Heroux, A.,Botuyan, M.V.,Yaffe, M.B.,Couch, F.J.,Rosenfeld, M.G.,Mer, G. Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Proc.Natl.Acad.Sci.USA, 109:14381-14386, 2012 Cited by PubMed: 22908299DOI: 10.1073/pnas.1212366109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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