3U3Z

Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142

3U3Z の概要

• エントリーDOI: 10.2210/pdb3u3z/pdb
• 分子名称: Microcephalin, Histone H2A.X peptide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: dna repair, cell cycle regulation, cell cycle
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton, centrosome: Q8NEM0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22819.21

構造登録者

Singh, N.,Thompson, J.R.,Heroux, A.,Mer, G. (登録日: 2011-10-06, 公開日: 2012-07-25, 最終更新日: 2023-12-06)

• 主引用文献: Singh, N.,Basnet, H.,Wiltshire, T.D.,Mohammad, D.H.,Thompson, J.R.,Heroux, A.,Botuyan, M.V.,Yaffe, M.B.,Couch, F.J.,Rosenfeld, M.G.,Mer, G.; Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.; Proc.Natl.Acad.Sci.USA, 109:14381-14386, 2012; PubMed: 22908299; DOI: 10.1073/pnas.1212366109

実験手法

X-RAY DIFFRACTION (1.5 Å)