3U2C
Aldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution
Summary for 3U2C
| Entry DOI | 10.2210/pdb3u2c/pdb |
| Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... (8 entities in total) |
| Functional Keywords | tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P15121 |
| Total number of polymer chains | 1 |
| Total formula weight | 37953.20 |
| Authors | Steuber, H. (deposition date: 2011-10-03, release date: 2011-11-02, Last modification date: 2023-09-13) |
| Primary citation | Steuber, H. An old NSAID revisited: crystal structure of aldose reductase in complex with sulindac at 1.0 A supports a novel mechanism for its anticancer and antiproliferative effects. Chemmedchem, 6:2155-2157, 2011 Cited by PubMed: 21997888DOI: 10.1002/cmdc.201100374 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1 Å) |
Structure validation
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