3U2C

Aldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution

3U2C の概要

• エントリーDOI: 10.2210/pdb3u2c/pdb
• 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... (8 entities in total)
• 機能のキーワード: tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37953.20

構造登録者

Steuber, H. (登録日: 2011-10-03, 公開日: 2011-11-02, 最終更新日: 2023-09-13)

• 主引用文献: Steuber, H.; An old NSAID revisited: crystal structure of aldose reductase in complex with sulindac at 1.0 A supports a novel mechanism for its anticancer and antiproliferative effects.; Chemmedchem, 6:2155-2157, 2011; PubMed: 21997888; DOI: 10.1002/cmdc.201100374

実験手法

X-RAY DIFFRACTION (1 Å)