3U1I

Dengue virus protease covalently bound to a peptide

3U1I の概要

• エントリーDOI: 10.2210/pdb3u1i/pdb
• 関連するPDBエントリー: 3UIJ
• 関連するBIRD辞書のPRD_ID: PRD_000988
• 分子名称: Serine protease subunit NS2B, Serine protease NS3, peptide of (BEZ)(NLE)KR(OAR), ... (5 entities in total)
• 機能のキーワード: serine protease, er membrane, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Dengue virus 3 (DENV-3); 詳細
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): Q5UB51 Q5UB51
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 53200.87

構造登録者

Noble, C.G. (登録日: 2011-09-29, 公開日: 2011-11-09, 最終更新日: 2023-11-15)

• 主引用文献: Noble, C.G.,Seh, C.C.,Chao, A.T.,Shi, P.Y.; Ligand-bound structures of the dengue virus protease reveal the active conformation; J.Virol., 86:438-446, 2012; PubMed: 22031935; DOI: 10.1128/JVI.06225-11

実験手法

X-RAY DIFFRACTION (2.3 Å)