3U0T
Fab-antibody complex
Summary for 3U0T
Entry DOI | 10.2210/pdb3u0t/pdb |
Descriptor | ponezumab LC Fab, ponezumab HC Fab, Amyloid beta A4 protein, ... (4 entities in total) |
Functional Keywords | antibody fab, immunotherapeutic, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 6 |
Total formula weight | 97303.07 |
Authors | LaPorte, S.L.,Pons, J.P. (deposition date: 2011-09-29, release date: 2012-01-11, Last modification date: 2013-07-03) |
Primary citation | La Porte, S.L.,Bollini, S.S.,Lanz, T.A.,Abdiche, Y.N.,Rusnak, A.S.,Ho, W.H.,Kobayashi, D.,Harrabi, O.,Pappas, D.,Mina, E.W.,Milici, A.J.,Kawabe, T.T.,Bales, K.,Lin, J.C.,Pons, J. Structural Basis of C-terminal beta-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease J.Mol.Biol., 421:525-536, 2012 Cited by PubMed: 22197375DOI: 10.1016/j.jmb.2011.11.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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