3TZM

TGF-beta Receptor type 1 in complex with SB431542

3TZM の概要

• エントリーDOI: 10.2210/pdb3tzm/pdb
• 分子名称: TGF-beta receptor type-1, 4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide (3 entities in total)
• 機能のキーワード: alk5, sb431542, kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P36897
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35612.94

構造登録者

Ogunjimi, A.A.,Zeqiraj, E.,Ceccarelli, D.F.,Sicheri, F. (登録日: 2011-09-27, 公開日: 2012-05-23, 最終更新日: 2023-09-13)

• 主引用文献: Ogunjimi, A.A.,Zeqiraj, E.,Ceccarelli, D.F.,Sicheri, F.,Wrana, J.L.,David, L.; Structural Basis for Specificity of TGFbeta Family Receptor Small Molecule Inhibitors; Cell Signal, 24:476-483, 2012; PubMed: 21983015; DOI: 10.1016/j.cellsig.2011.09.027

実験手法

X-RAY DIFFRACTION (1.7 Å)