3TZ3

Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 2

3TZ3 の概要

• エントリーDOI: 10.2210/pdb3tz3/pdb
• 分子名称: Acetyl-CoA carboxylase, 6-{[1-(anthracen-9-ylcarbonyl)piperidin-4-yl]methyl}-2-methylquinoline (3 entities in total)
• 機能のキーワード: carboxyltransferase, ligase
• 由来する生物種: Saccharomyces cerevisiae S288c (Baker's yeast)
• 細胞内の位置: Cytoplasm: Q00955
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 262996.23

構造登録者

Rajamohan, F.,Marr, E.,Reyes, A.,Landro, J.A.,Anderson, M.D.,Corbett, J.W.,Dirico, K.J.,Harwood, J.H.,Tu, M.,Vajdos, F.F. (登録日: 2011-09-26, 公開日: 2011-10-19, 最終更新日: 2023-09-13)

• 主引用文献: Rajamohan, F.,Marr, E.,Reyes, A.R.,Landro, J.A.,Anderson, M.D.,Corbett, J.W.,Dirico, K.J.,Harwood, J.H.,Tu, M.,Vajdos, F.F.; Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.; J.Biol.Chem., 286:41510-41519, 2011; PubMed: 21953464; DOI: 10.1074/jbc.M111.275396

実験手法

X-RAY DIFFRACTION (2.7 Å)