3TZ0
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex
Summary for 3TZ0
Entry DOI | 10.2210/pdb3tz0/pdb |
Related | 3TZ2 3TZ4 3TZ5 4DZY 4H7Q 4H81 4H85 |
Descriptor | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, (2S)-2-chloro-4-methylpentanoic acid (3 entities in total) |
Functional Keywords | ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (rat) |
Total number of polymer chains | 1 |
Total formula weight | 47524.85 |
Authors | Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (deposition date: 2011-09-26, release date: 2012-10-03, Last modification date: 2024-02-28) |
Primary citation | Tso, S.C.,Qi, X.,Gui, W.J.,Chuang, J.L.,Morlock, L.K.,Wallace, A.L.,Ahmed, K.,Laxman, S.,Campeau, P.M.,Lee, B.H.,Hutson, S.M.,Tu, B.P.,Williams, N.S.,Tambar, U.K.,Wynn, R.M.,Chuang, D.T. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Proc.Natl.Acad.Sci.USA, 110:9728-9733, 2013 Cited by PubMed: 23716694DOI: 10.1073/pnas.1303220110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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