3TYN

Structure of neuronal nitric oxide synthase heme domain in complex with 2-(((2-(((3S,4S)-4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)oxy)ethyl)amino)methyl)phenol

3TYN の概要

• エントリーDOI: 10.2210/pdb3tyn/pdb
• 関連するPDBエントリー: 3TYL 3TYM 3TYO
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, inhibitor binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100236.94

構造登録者

Li, H.,Poulos, T.L. (登録日: 2011-09-26, 公開日: 2012-03-14, 最終更新日: 2023-09-13)

• 主引用文献: Labby, K.J.,Xue, F.,Kraus, J.M.,Ji, H.,Mataka, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.; Bioorg.Med.Chem., 20:2435-2443, 2012; PubMed: 22370337; DOI: 10.1016/j.bmc.2012.01.037

実験手法

X-RAY DIFFRACTION (1.968 Å)