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3TYL

Structure of neuronal nitric oxide synthase heme domain in complex with 6-(((3S,4S)-4-(2-((2-fluorobenzyl)amino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine

Summary for 3TYL
Entry DOI10.2210/pdb3tyl/pdb
Related3TYM 3TYN 3TYO
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, inhibitor binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceRattus norvegicus (brown rat,rat,rats)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains2
Total formula weight100240.93
Authors
Li, H.,Poulos, T.L. (deposition date: 2011-09-26, release date: 2012-03-14, Last modification date: 2023-09-13)
Primary citationLabby, K.J.,Xue, F.,Kraus, J.M.,Ji, H.,Mataka, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.
Bioorg.Med.Chem., 20:2435-2443, 2012
Cited by
PubMed: 22370337
DOI: 10.1016/j.bmc.2012.01.037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

數據於2024-03-27公開中

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