3TVL

Complex between the human thiamine triphosphatase and triphosphate

Summary for 3TVL

• Entry DOI: 10.2210/pdb3tvl/pdb
• Related: 2jmu 3bhd
• Descriptor: Thiamine-triphosphatase, TRIPHOSPHATE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: hydrolase, magnesium binding
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9BU02
• Total number of polymer chains: 2
• Total formula weight: 51891.85

Authors

Delvaux, D.,Herman, R.,Sauvage, E.,Wins, P.,Bettendorff, L.,Charlier, P.,Kerff, F. (deposition date: 2011-09-20, release date: 2012-10-10, Last modification date: 2023-09-13)

• Primary citation: Delvaux, D.,Kerff, F.,Murty, M.R.,Lakaye, B.,Czerniecki, J.,Kohn, G.,Wins, P.,Herman, R.,Gabelica, V.,Heuze, F.,Tordoir, X.,Maree, R.,Matagne, A.,Charlier, P.,De Pauw, E.,Bettendorff, L.; Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase.; Biochim.Biophys.Acta, 1830:4513-4523, 2013; PubMed: 23707715; DOI: 10.1016/j.bbagen.2013.05.014

Experimental method

X-RAY DIFFRACTION (2.3 Å)