3TV3

Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with Man9

3TV3 の概要

• エントリーDOI: 10.2210/pdb3tv3/pdb
• 分子名称: PGT128 light chain, Ig lambda-2 chain C regions, PGT128 heavy chain, Ig gamma-1 chain C region, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose, ... (7 entities in total)
• 機能のキーワード: fab, hiv-1 neutralizing antibody, gp120, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49795.26

構造登録者

Pejchal, R.,Wilson, I.A. (登録日: 2011-09-19, 公開日: 2011-10-19, 最終更新日: 2021-04-28)

• 主引用文献: Pejchal, R.,Doores, K.J.,Walker, L.M.,Khayat, R.,Huang, P.S.,Wang, S.K.,Stanfield, R.L.,Julien, J.P.,Ramos, A.,Crispin, M.,Depetris, R.,Katpally, U.,Marozsan, A.,Cupo, A.,Maloveste, S.,Liu, Y.,McBride, R.,Ito, Y.,Sanders, R.W.,Ogohara, C.,Paulson, J.C.,Feizi, T.,Scanlan, C.N.,Wong, C.H.,Moore, J.P.,Olson, W.C.,Ward, A.B.,Poignard, P.,Schief, W.R.,Burton, D.R.,Wilson, I.A.; A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.; Science, 334:1097-1103, 2011; PubMed: 21998254; DOI: 10.1126/science.1213256

実験手法

X-RAY DIFFRACTION (1.29 Å)