3TSH

Crystal structure of Phl p 4, a grass pollen allergen with glucose dehydrogenase activity

3TSH の概要

• エントリーDOI: 10.2210/pdb3tsh/pdb
• 分子名称: Pollen allergen Phl p 4, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: flavoprotein, bi-covalent flavinylation, oxidoreductase, glucose dehydrogenase, n-glycosylation, allergy, pollen, allergen, dehydrogenase, grass pollen
• 由来する生物種: Phleum pratense (timothy)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56698.30

構造登録者

Zafred, D.,Nandy, A.,Keller, W. (登録日: 2011-09-13, 公開日: 2012-09-19, 最終更新日: 2024-11-06)

主引用文献

Zafred, D.,Nandy, A.,Pump, L.,Kahlert, H.,Keller, W.
Crystal structure and immunologic characterization of the major grass pollen allergen Phl p 4.
J. Allergy Clin. Immunol., 132:696-703.e10, 2013

PubMed Abstract: Phl p 4 is a major pollen allergen but exhibits lower allergenicity than other major allergens. The natural protein is glycosylated and shows cross-reactivity with related and structurally unrelated allergens.

PubMed: 23683465
DOI: 10.1016/j.jaci.2013.03.021

実験手法

X-RAY DIFFRACTION (1.9 Å)