3TS8

Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element

3TS8 の概要

• エントリーDOI: 10.2210/pdb3ts8/pdb
• 分子名称: Cellular tumor antigen p53, CDKN1A(p21) sense strand, CDKN1A(p21) anti-sense strand, ... (5 entities in total)
• 機能のキーワード: beta sandwich, multidomain, oligomerization, tp53, p53, tumor suppressor, tetramer, dna binding, antitumor protein-dna complex, antitumor protein/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 122707.37

構造登録者

Halazonetis, T.D.,Emamzadah, S. (登録日: 2011-09-12, 公開日: 2011-11-23, 最終更新日: 2024-02-28)

• 主引用文献: Emamzadah, S.,Tropia, L.,Halazonetis, T.D.; Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element.; Mol Cancer Res, 9:1493-1499, 2011; PubMed: 21933903; DOI: 10.1158/1541-7786.MCR-11-0351

実験手法

X-RAY DIFFRACTION (2.8 Å)