3TP0
Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands
Summary for 3TP0
Entry DOI | 10.2210/pdb3tp0/pdb |
Related | 3TP3 |
Descriptor | HTH-type transcriptional regulator EthR, 3-oxo-3-{4-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}propanenitrile (3 entities in total) |
Functional Keywords | tetr-family, transcritptional regulatory repressor, dna binding protein, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 24084.06 |
Authors | Carette, X.,Blondiaux, N.,Willery, E.,Hoos, S.,Lecat-Guillet, N.,Lens, Z.,Wohlkonig, A.,Wintjens, R.,Soror, S.,Fr nois, F.,Diri, B.,Villeret, V.,England, P.,Lippens, G.,Deprez, B.,Locht, C.,Willand, N.,Baulard, A. (deposition date: 2011-09-07, release date: 2011-12-21, Last modification date: 2024-02-28) |
Primary citation | Carette, X.,Blondiaux, N.,Willery, E.,Hoos, S.,Lecat-Guillet, N.,Lens, Z.,Wohlkonig, A.,Wintjens, R.,Soror, S.H.,Frenois, F.,Dirie, B.,Villeret, V.,England, P.,Lippens, G.,Deprez, B.,Locht, C.,Willand, N.,Baulard, A.R. Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands. Nucleic Acids Res., 40:3018-3030, 2011 Cited by PubMed: 22156370DOI: 10.1093/nar/gkr1113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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