3TNS
Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester inhibitor SG83
Summary for 3TNS
Entry DOI | 10.2210/pdb3tns/pdb |
Descriptor | SARS coronavirus main protease, ETHYL (5S,8S,11R)-8-BENZYL-5-(2-TERT-BUTOXY-2-OXOETHYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE (3 entities in total) |
Functional Keywords | 3c-like protease, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | SARS coronavirus (SARS-CoV) |
Cellular location | Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8 |
Total number of polymer chains | 1 |
Total formula weight | 34557.43 |
Authors | Zhu, L.,Hilgenfeld, R. (deposition date: 2011-09-01, release date: 2012-09-05, Last modification date: 2024-10-16) |
Primary citation | Zhu, L.,Hilgenfeld, R. Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters To be Published, |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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