3TNM

Crystal structure of A32 Fab, an ADCC mediating anti-HIV-1 antibody

Summary for 3TNM

Entry DOI	10.2210/pdb3tnm/pdb
Related	3QEG 3QEH 3TNN
Descriptor	Fab heavy chain of human anti-HIV-1 Env antibody A32, Fab light chain of human anti-HIV-1 Env antibody A32, ACETATE ION, ... (5 entities in total)
Functional Keywords	adcc, non-neutralizing, anti-hiv-1 env antibody a32, cd4i antibody, fab, viral glycoprotein gp120, hiv-1 env, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	95356.96
Authors	Wu, X.,Pazgier, M. (deposition date: 2011-09-01, release date: 2012-09-26, Last modification date: 2021-04-21)
Primary citation	Guan, Y.,Pazgier, M.,Sajadi, M.M.,Kamin-Lewis, R.,Al-Darmarki, S.,Flinko, R.,Lovo, E.,Wu, X.,Robinson, J.E.,Seaman, M.S.,Fouts, T.R.,Gallo, R.C.,DeVico, A.L.,Lewis, G.K. Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding. Proc.Natl.Acad.Sci.USA, 110:E69-E78, 2013 Cited by PubMed: 23237851 DOI: 10.1073/pnas.1217609110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation