3TM2

Crystal structure of mature ThnT with a covalently bound product mimic

Summary for 3TM2

Entry DOI	10.2210/pdb3tm2/pdb
Related	3S3U
Descriptor	cysteine transferase, (2R)-N-(4-chloro-3-oxobutyl)-2,4-dihydroxy-3,3-dimethylbutanamide (3 entities in total)
Functional Keywords	dom-fold, amidohydrolase, autoproteolytic, carbapenem, pantetheine, inhibitor, dmpa/oat superfamily, pantetheine hydrolase, thienamycin biosynthesis, o-(2-oxo-4-pantoamindobutyl)threonine, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Streptomyces cattleya
Total number of polymer chains	2
Total formula weight	83247.57
Authors	Schildbach, J.F.,Wright, N.T.,Buller, A.R. (deposition date: 2011-08-30, release date: 2012-07-04, Last modification date: 2023-09-13)
Primary citation	Buller, A.R.,Labonte, J.W.,Freeman, M.F.,Wright, N.T.,Schildbach, J.F.,Townsend, C.A. Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis. J.Mol.Biol., 422:508-518, 2012 Cited by PubMed: 22706025 DOI: 10.1016/j.jmb.2012.06.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation