3TL9

crystal structure of HIV protease model precursor/Saquinavir complex

3TL9 の概要

• エントリーDOI: 10.2210/pdb3tl9/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23329.24

構造登録者

Agniswamy, J.,Sayer, J.,Weber, I.,Louis, J. (登録日: 2011-08-29, 公開日: 2012-04-25, 最終更新日: 2023-09-13)

• 主引用文献: Agniswamy, J.,Sayer, J.M.,Weber, I.T.,Louis, J.M.; Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.; Biochemistry, 51:1041-1050, 2012; PubMed: 22242794; DOI: 10.1021/bi201809s

実験手法

X-RAY DIFFRACTION (1.32 Å)