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3TKH

Crystal structure of Chk1 in complex with inhibitor S01

Summary for 3TKH
Entry DOI10.2210/pdb3tkh/pdb
DescriptorSerine/threonine-protein kinase Chk1, SULFATE ION, 1-(morpholin-4-yl)-2-[4-(2-{[5-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}pyridin-4-yl)piperazin-1-yl]ethanone, ... (4 entities in total)
Functional Keywordschk1, kinase, cell checkpoint, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O14757
Total number of polymer chains1
Total formula weight37483.79
Authors
Yan, Y.,Ikuta, M. (deposition date: 2011-08-26, release date: 2012-04-11, Last modification date: 2023-09-13)
Primary citationDudkin, V.Y.,Rickert, K.,Kreatsoulas, C.,Wang, C.,Arrington, K.L.,Fraley, M.E.,Hartman, G.D.,Yan, Y.,Ikuta, M.,Stirdivant, S.M.,Drakas, R.A.,Walsh, E.S.,Hamilton, K.,Buser, C.A.,Lobell, R.B.,Sepp-Lorenzino, L.
Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.
Bioorg.Med.Chem.Lett., 22:2609-2612, 2012
Cited by
PubMed: 22374217
DOI: 10.1016/j.bmcl.2012.01.110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.79 Å)
Structure validation

217705

數據於2024-03-27公開中

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