3TK3
Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl)imidazole
Summary for 3TK3
| Entry DOI | 10.2210/pdb3tk3/pdb |
| Descriptor | Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE, ... (4 entities in total) |
| Functional Keywords | p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2 |
| Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
| Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P00178 |
| Total number of polymer chains | 4 |
| Total formula weight | 219688.44 |
| Authors | Gay, S.C.,Jang, H.H.,Wilderman, P.R.,Zhang, Q.,Stout, C.D.,Halpert, J.R. (deposition date: 2011-08-25, release date: 2011-11-16, Last modification date: 2023-09-13) |
| Primary citation | Wilderman, P.R.,Gay, S.C.,Jang, H.H.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme. Febs J., 279:1607-1620, 2012 Cited by PubMed: 22051155DOI: 10.1111/j.1742-4658.2011.08411.x PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8001 Å) |
Structure validation
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