3TI4

Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with laninamivir octanoate

Summary for 3TI4

• Entry DOI: 10.2210/pdb3ti4/pdb
• Related: 3NSS 3TI3 3TI5 3TI6 3TI8 3TIA 3TIB 3TIC
• Descriptor: Neuraminidase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: 6-bladed beta-propeller, calcium binding, glycosylation, antiviral, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Total number of polymer chains: 2
• Total formula weight: 88492.43

Authors

Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F. (deposition date: 2011-08-20, release date: 2011-11-16, Last modification date: 2023-11-01)

• Primary citation: Vavricka, C.J.,Li, Q.,Wu, Y.,Qi, J.,Wang, M.,Liu, Y.,Gao, F.,Liu, J.,Feng, E.,He, J.,Wang, J.,Liu, H.,Jiang, H.,Gao, G.F.; Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition; Plos Pathog., 7:e1002249-e1002249, 2011; PubMed: 22028647; DOI: 10.1371/journal.ppat.1002249

Experimental method

X-RAY DIFFRACTION (1.602 Å)