3THS

Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate pentaglutamate

3THS の概要

• エントリーDOI: 10.2210/pdb3ths/pdb
• 関連するPDBエントリー: 2IDK 3THR
• 関連するBIRD辞書のPRD_ID: PRD_000833
• 分子名称: Glycine N-methyltransferase, 5-methyltetrahydrofolate pentaglutamate, BETA-MERCAPTOETHANOL, ... (5 entities in total)
• 機能のキーワード: glycine n-methyltransferase, gnmt, folate, folate binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cytoplasm: P13255
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 132140.65

構造登録者

Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Newcomer, M.E.,Wagner, C. (登録日: 2011-08-19, 公開日: 2011-11-16, 最終更新日: 2023-09-13)

• 主引用文献: Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Newcomer, M.E.,Wagner, C.; Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.; Biochim.Biophys.Acta, 1824:286-291, 2011; PubMed: 22037183; DOI: 10.1016/j.bbapap.2011.10.008

実験手法

X-RAY DIFFRACTION (2.5 Å)