3TFU

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, post-reaction complex with a 3,6-dihydropyrid-2-one heterocycle inhibitor

3TFU の概要

• エントリーDOI: 10.2210/pdb3tfu/pdb
• 関連するPDBエントリー: 3TFT
• 分子名称: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, [5-hydroxy-4-({[6-(3-hydroxypropyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}methyl)-6-methylpyridin-3-yl]methyl dihydrogen phosphate, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• 細胞内の位置: Cytoplasm (By similarity): P0A4X6
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97949.85

構造登録者

Geders, T.W.,Finzel, B.C. (登録日: 2011-08-16, 公開日: 2011-10-19, 最終更新日: 2023-09-13)

• 主引用文献: Shi, C.,Geders, T.W.,Park, S.W.,Wilson, D.J.,Boshoff, H.I.,Abayomi, O.,Barry, C.E.,Schnappinger, D.,Finzel, B.C.,Aldrich, C.C.; Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis.; J.Am.Chem.Soc., 133:18194-18201, 2011; PubMed: 21988601; DOI: 10.1021/ja204036t

実験手法

X-RAY DIFFRACTION (1.94 Å)