3TFT

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, pre-reaction complex with a 3,6-dihydropyrid-2-one heterocycle inhibitor

Summary for 3TFT

Entry DOI	10.2210/pdb3tft/pdb
Related	3TFU
Descriptor	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	transferase, plp
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (By similarity): P0A4X6
Total number of polymer chains	2
Total formula weight	97645.46
Authors	Geders, T.W.,Finzel, B.C. (deposition date: 2011-08-16, release date: 2011-10-19, Last modification date: 2023-09-13)
Primary citation	Shi, C.,Geders, T.W.,Park, S.W.,Wilson, D.J.,Boshoff, H.I.,Abayomi, O.,Barry, C.E.,Schnappinger, D.,Finzel, B.C.,Aldrich, C.C. Mechanism-based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobaterium tuberculosis. J.Am.Chem.Soc., 133:18194-18201, 2011 Cited by PubMed: 21988601 DOI: 10.1021/ja204036t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation