3TEL

LytR-CPS2A-Psr family protein with bound octaprenyl pyrophosphate lipid and manganese ion

3TEL の概要

• エントリーDOI: 10.2210/pdb3tel/pdb
• 分子名称: Cps2A, Integral membrane regulatory protein Wzg, (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl trihydrogen diphosphate, MANGANESE (II) ION, ... (6 entities in total)
• 機能のキーワード: cell wall techoic acid synthesis, replication, transferase
• 由来する生物種: Streptococcus pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45111.36

構造登録者

Kawai, Y.,Marles-Wright, J.,Cleverley, R.M.,Emmins, R.,Ishikawa, S.,Kuwano, M.,Heinz, N.,Khai Bui, N.,Hoyland, C.N.,Ogasawara, N.,Lewis, R.J.,Vollmer, W.,Daniel, R.A.,Errington, J. (登録日: 2011-08-15, 公開日: 2011-10-12, 最終更新日: 2024-02-28)

主引用文献

Kawai, Y.,Marles-Wright, J.,Cleverley, R.M.,Emmins, R.,Ishikawa, S.,Kuwano, M.,Heinz, N.,Bui, N.K.,Hoyland, C.N.,Ogasawara, N.,Lewis, R.J.,Vollmer, W.,Daniel, R.A.,Errington, J.
A widespread family of bacterial cell wall assembly proteins.
Embo J., 30:4931-4941, 2011

PubMed Abstract: Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and multiple aspects of pathogenesis. We have identified the widespread LytR-Cps2A-Psr (LCP) protein family, of previously unknown function, as novel enzymes required for AP synthesis. Structural and biochemical analysis of several LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked precursor to cell wall peptidoglycan (PG). In Bacillus subtilis, LCP proteins are found in association with the MreB cytoskeleton, suggesting that MreB proteins coordinate the insertion of the major polymers, PG and AP, into the cell wall.

PubMed: 21964069
DOI: 10.1038/emboj.2011.358

実験手法

X-RAY DIFFRACTION (1.8 Å)