3TCT

Structure of wild-type TTR in complex with tafamidis

3TCT の概要

• エントリーDOI: 10.2210/pdb3tct/pdb
• 関連するPDBエントリー: 2QGC 2QGD 2QGE
• 分子名称: Transthyretin, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid (3 entities in total)
• 機能のキーワード: amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, secreted, thyroid hormone, transport, kinetic stabilizer, inhibition of the amyloid cascade, binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28170.95

構造登録者

Connelly, S.,Kelly, J.W.,Wilson, I.A. (登録日: 2011-08-09, 公開日: 2012-05-30, 最終更新日: 2023-09-13)

• 主引用文献: Bulawa, C.E.,Connelly, S.,Devit, M.,Wang, L.,Weigel, C.,Fleming, J.A.,Packman, J.,Powers, E.T.,Wiseman, R.L.,Foss, T.R.,Wilson, I.A.,Kelly, J.W.,Labaudiniere, R.; Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.; Proc.Natl.Acad.Sci.USA, 109:9629-9634, 2012; PubMed: 22645360; DOI: 10.1073/pnas.1121005109

実験手法

X-RAY DIFFRACTION (1.3 Å)