3T9J

Crystal structure HP-NAP from strain YS39 in apo form

3T9J の概要

• エントリーDOI: 10.2210/pdb3t9j/pdb
• 関連するPDBエントリー: 3TA8
• 分子名称: Neutrophil-activating protein, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: dodecamer, four-helix bundle, metal transport
• 由来する生物種: Helicobacter pylori
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19068.69

構造登録者

Tsuruta, O.,Yokoyama, H.,Fujii, S. (登録日: 2011-08-03, 公開日: 2012-02-08, 最終更新日: 2023-11-01)

主引用文献

Tsuruta, O.,Yokoyama, H.,Fujii, S.
A new crystal lattice structure of Helicobacter pylori neutrophil-activating protein (HP-NAP)
Acta Crystallogr.,Sect.F, 68:134-140, 2012

PubMed Abstract: A new crystal lattice structure of Helicobacter pylori neutrophil-activating protein (HP-NAP) has been determined in two forms: the native state (Apo) at 2.20 Å resolution and an iron-loaded form (Fe-load) at 2.50 Å resolution. The highly solvated packing of the dodecameric shell is suitable for crystallographic study of the metal ion-uptake pathway. Like other bacterioferritins, HP-NAP forms a spherical dodecamer with 23 symmetry including two kinds of channels. Iron loading causes a series of conformational changes of amino-acid residues (Trp26, Asp52 and Glu56) at the ferroxidase centre.

PubMed: 22297984
DOI: 10.1107/S1744309111052675

実験手法

X-RAY DIFFRACTION (2.2 Å)