3T9I

Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution

Summary for 3T9I

Entry DOI	10.2210/pdb3t9i/pdb
Descriptor	Proto-oncogene serine/threonine-protein kinase pim-1, 2-methoxy-4-(3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenol (3 entities in total)
Functional Keywords	kinase, phosphotransferase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	37914.04
Authors	Bellamacina, C.,Shu, W.,Le, V.,Nishiguchi, G.,Bussiere, D. (deposition date: 2011-08-02, release date: 2011-10-12, Last modification date: 2011-11-02)
Primary citation	Nishiguchi, G.A.,Atallah, G.,Bellamacina, C.,Burger, M.T.,Ding, Y.,Feucht, P.H.,Garcia, P.D.,Han, W.,Klivansky, L.,Lindvall, M. Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. Bioorg.Med.Chem.Lett., 21:6366-6369, 2011 Cited by PubMed: 21945284 DOI: 10.1016/j.bmcl.2011.08.105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation