3T9I
Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution
Summary for 3T9I
Entry DOI | 10.2210/pdb3t9i/pdb |
Descriptor | Proto-oncogene serine/threonine-protein kinase pim-1, 2-methoxy-4-(3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenol (3 entities in total) |
Functional Keywords | kinase, phosphotransferase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 37914.04 |
Authors | Bellamacina, C.,Shu, W.,Le, V.,Nishiguchi, G.,Bussiere, D. (deposition date: 2011-08-02, release date: 2011-10-12, Last modification date: 2011-11-02) |
Primary citation | Nishiguchi, G.A.,Atallah, G.,Bellamacina, C.,Burger, M.T.,Ding, Y.,Feucht, P.H.,Garcia, P.D.,Han, W.,Klivansky, L.,Lindvall, M. Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. Bioorg.Med.Chem.Lett., 21:6366-6369, 2011 Cited by PubMed: 21945284DOI: 10.1016/j.bmcl.2011.08.105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report