3T95

Crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2

3T95 の概要

• エントリーDOI: 10.2210/pdb3t95/pdb
• 関連するPDBエントリー: 1TJY 1TM2 3EJW
• 分子名称: Autoinducer 2-binding protein lsrB, (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran (3 entities in total)
• 機能のキーワード: periplasmic binding protein fold, periplasmic space, signaling protein
• 由来する生物種: Yersinia pestis
• 細胞内の位置: Periplasm (Potential): Q74PW2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36503.20

構造登録者

Kavanaugh, J.S.,Gakhar, L.,Horswill, A.R. (登録日: 2011-08-02, 公開日: 2011-12-07, 最終更新日: 2023-09-13)

主引用文献

Kavanaugh, J.S.,Gakhar, L.,Horswill, A.R.
The structure of LsrB from Yersinia pestis complexed with autoinducer-2.
Acta Crystallogr.,Sect.F, 67:1501-1505, 2011

PubMed Abstract: The crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2 (AI-2; space group P2(1)2(1)2(1), unit-cell parameters a = 40.61, b = 61.03, c = 125.23 Å) has been solved by molecular replacement using the structure of LsrB from Salmonella typhimurium (PDB entry 1tjy) and refined to R = 0.180 (R(free) = 0.213) at 1.75 Å resolution. The electron density for bound AI-2 and the stereochemistry of the AI-2-binding site are consistent with bound AI-2 adopting the (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran conformation, just as has been observed in the crystal structures of the Salmonella typhimurium and Sinorhizobium meliloti LsrB-AI-2 complexes.

PubMed: 22139152
DOI: 10.1107/S1744309111042953

実験手法

X-RAY DIFFRACTION (1.75 Å)