3T6Y

5'-Diphenyl Nucleoside Inhibitors of Plasmodium falciparum dUTPase

Summary for 3T6Y

• Entry DOI: 10.2210/pdb3t6y/pdb
• Related: 3T70
• Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, peptide ALA-HIS-ALA, 2',5'-dideoxy-5'-{[(R)-(1-methyl-1H-imidazol-2-yl)(phenyl)methyl]amino}uridine, ... (5 entities in total)
• Functional Keywords: dutp binding, nucleus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Plasmodium falciparum; More
• Total number of polymer chains: 4
• Total formula weight: 63867.66

Authors

Hampton, S.E.,Baragana, B.,Schipani, A.,Bosch-Navarrete, C.,Musso-Buendia, A.,Recio, E.,Kaiser, M.,Whittingham, J.L.,Roberts, S.M.,Shevtsov, M.,Brannigan, J.A.,Kahnberg, P.,Brun, R.,Wilson, K.S.,Gonzalez-Pacanowska, D.,Johansson, N.G.,Gilbert, I.H. (deposition date: 2011-07-29, release date: 2012-08-29, Last modification date: 2023-11-01)

• Primary citation: Hampton, S.E.,Baragana, B.,Schipani, A.,Bosch-Navarrete, C.,Musso-Buendia, J.A.,Recio, E.,Kaiser, M.,Whittingham, J.L.,Roberts, S.M.,Shevtsov, M.,Brannigan, J.A.,Kahnberg, P.,Brun, R.,Wilson, K.S.,Gonzalez-Pacanowska, D.,Johansson, N.G.,Gilbert, I.H.; Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.; Chemmedchem, 6:1816-1831, 2011; PubMed: 22049550; DOI: 10.1002/cmdc.201100255

Experimental method

X-RAY DIFFRACTION (2.6 Å)