3T42

Human aldose reductase in complex with a nitrile-containing IDD inhibitor

3T42 の概要

• エントリーDOI: 10.2210/pdb3t42/pdb
• 分子名称: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {5-chloro-2-[(4-cyano-3-nitrobenzyl)carbamoyl]phenoxy}acetic acid, ... (5 entities in total)
• 機能のキーワード: tim barrel, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37505.90

構造登録者

Xu, L.,Cohen, A.E.,Boxer, S.G. (登録日: 2011-07-25, 公開日: 2011-10-05, 最終更新日: 2023-09-13)

• 主引用文献: Xu, L.,Cohen, A.E.,Boxer, S.G.; Electrostatic Fields near the Active Site of Human Aldose Reductase: 2. New Inhibitors and Complications Caused by Hydrogen Bonds.; Biochemistry, 50:8311-8322, 2011; PubMed: 21859105; DOI: 10.1021/bi200930f

実験手法

X-RAY DIFFRACTION (1.28 Å)