3T06
Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex with Human RhoA
Summary for 3T06
Entry DOI | 10.2210/pdb3t06/pdb |
Descriptor | Rho guanine nucleotide exchange factor 11, Transforming protein RhoA (2 entities in total) |
Functional Keywords | dh-ph rhoa complex, pdzrhogef, guanine nucleotide exchange factor, rhoa, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : O15085 Cell membrane; Lipid-anchor; Cytoplasmic side: P61586 |
Total number of polymer chains | 4 |
Total formula weight | 137247.51 |
Authors | Bielnicki, J.A.,Derewenda, U.,Derewenda, Z.S. (deposition date: 2011-07-19, release date: 2011-08-03, Last modification date: 2023-09-13) |
Primary citation | Bielnicki, J.A.,Shkumatov, A.V.,Derewenda, U.,Somlyo, A.V.,Svergun, D.I.,Derewenda, Z.S. Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF. J.Biol.Chem., 286:35163-35175, 2011 Cited by PubMed: 21816819DOI: 10.1074/jbc.M111.270918 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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