3T06

Crystal Structure of the DH/PH fragment of PDZRHOGEF with N-terminal regulatory elements in complex with Human RhoA

3T06 の概要

• エントリーDOI: 10.2210/pdb3t06/pdb
• 分子名称: Rho guanine nucleotide exchange factor 11, Transforming protein RhoA (2 entities in total)
• 機能のキーワード: dh-ph rhoa complex, pdzrhogef, guanine nucleotide exchange factor, rhoa, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm : O15085; Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 137247.51

構造登録者

Bielnicki, J.A.,Derewenda, U.,Derewenda, Z.S. (登録日: 2011-07-19, 公開日: 2011-08-03, 最終更新日: 2023-09-13)

• 主引用文献: Bielnicki, J.A.,Shkumatov, A.V.,Derewenda, U.,Somlyo, A.V.,Svergun, D.I.,Derewenda, Z.S.; Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF.; J.Biol.Chem., 286:35163-35175, 2011; PubMed: 21816819; DOI: 10.1074/jbc.M111.270918

実験手法

X-RAY DIFFRACTION (2.84 Å)